Question: Do you think the year 2012 has any prophetic significance?
My Response: We won't really know if 2012 has any genuine prophetic significance until 2012!
I remember the hubbub over "98 Reasons Jesus Will Return in 1988" and the sequel "99 Reasons Jesus Will Return in 1999"! I followed that with an New Year's message entitled, "00 Reasons Jesus Will Return in 2000."
The purpose of God's prophetic word has never been to enable us to predict the future. He has given us His Word so that we can recognize prophecy as it is fulfilled. The common mistake Christians make is to try to use Scripture and "signs of the times" to know ahead of time what will take place. There are many "secret things" that belong only to God. We strive to know things that are not for us to know.
Why, then, did God give us any prophetic word? What is the reason for the signs of the times? The purpose of biblical prophecy is preparation not prediction. We have been given enough information so that we can be prepared, not so we can predict! The key words in biblical prophecy are Watch! and Be Ready!
As an afterthought ... why would we put any validity into the Mayan calendar, anyway??